Pharmacology Notes

Pharmacology of Disopyramide Indication For the treatment of documented ventricular arrhythmias, such as sustained ventricular tachycardia, ventricular pre-excitation and cardiac dysrhythmias. It is a Class Ia antiarrhythmic drug. Pharmacodynamics Disopyramide is an antiarrhythmic drug indicated for the treatment of documented ventricular arrhythmias, such as sustained ventricular tachycardia that...

Pharmacology of Ranolazine Indication For the treatment of chronic angina. It should be used in combination with amlodipine, beta-blockers or nitrates. Pharmacodynamics Ranolazine has antianginal and anti-ischemic effects that do not depend upon reductions in heart rate or blood pressure. It is the first new anti-anginal developed in...

Pharmacology of Milrinone Indication Indicated for the treatment of congestive heart failure. Pharmacodynamics Milrinone, a synthetic dimethylxanthine derivative structurally related to theophylline and caffeine, is used in the treatment of peripheral vascular diseases and in the management of cerebrovascular insufficiency, sickle cell disease, and diabetic neuropathy. Mechanism of...

Pharmacology of Midodrine   Indication For the treatment of symptomatic orthostatic hypotension (OH). Pharmacodynamics Midodrine is a prodrug, i.e., the therapeutic effect of orally administered midodrine is due to the major metabolite desglymidodrine formed by deglycination of midodrine. Desglymidodrine diffuses poorly across the blood-brain barrier, and is therefore not...

Pharmacology of Dofetilide  Indication For the maintenance of normal sinus rhythm (delay in time to recurrence of atrial fibrillation/atrial flutter [AF/AFl]) in patients with atrial fibrillation/atrial flutter of greater than one week duration who have been converted to normal sinus rhythm Pharmacodynamics Dofetilide is an antiarrhythmic drug with...

Pharmacology of PhenterminePhentermineIndication For the treatment and management of obesity. Pharmacodynamics Phentermine is indicated in the management of exogenous obesity as a short term (a few weeks) adjunct in a regimen of weight reduction based on caloric restriction. Phentermine hydrochloride is a sympathomimetic amine with pharmacologic activity similar...

Proton Pump InhibitorsThe final common pathway in gastric acid secretion is the proton pump adenosine triphosphatase. Th e physiological essence of this enzyme is the exchange of hydrogen ions for potassium ions. Th us, hydrogen is secreted by the parietal cell into the gastric lumen in exchange for...