Kaolin and pectin
Kaolin and pectin
Kaolin and pectin mixtures are locally acting OTC antidiarrheals. They work by adsorbing irritants and soothing the intestinal mucosa.
Pharmacokinetics
Kaolin and pectin aren’t absorbed and, therefore, aren’t distributed throughout the body. They’re excreted in stool.
Pharmacodynamics
Kaolin and pectin act as adsorbents, binding with bacteria, toxins, and other irritants in the intestinal mucosa. Pectin decreases the pH in the intestinal lumen and provides a soothing effect on the irritated mucosa.
Pharmacotherapeutics
Kaolin and pectin are used to relieve mild to moderate acute diarrhea. They may also be used to temporarily relieve chronic diarrhea until the cause is determined and definitive treatment begun.
Drug interactions
These antidiarrheals can interfere with the absorption of digoxin and other drugs by the intestinal mucosa if administered at the same time.
Warning!
Adverse reactions to kaolin and pectin
Kaolin and pectin mixtures cause few adverse reactions. However, constipation may occur, especially in an elderly or a debilitated patient and with overdose or prolonged use.
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