Mast cell stabilizers
Mast cell stabilizers
Mast cell stabilizers are used to prevent asthma attacks, especially in a child or a patient with mild disease. They’re also used in an adult or child with mild to moderate persistent asthma. Drugs in this class include:
- cromolyn
- nedocromil.
Pharmacokinetics
Mast cell stabilizers are minimally absorbed from the GI tract; they’re available in inhaled forms that exert their effects locally.
Pharmacodynamics
These drugs stabilize the mast cell membrane, possibly by inhibiting calcium channels, thus preventing the release of inflammatory mediators.
Pharmacotherapeutics
Mast cell stabilizers are used for the prevention and long-term control of asthma symptoms. They do this by controlling the inflammatory process.
Warning!
Adverse reactions to leukotriene modifiers
Adverse reactions that may occur with leukotriene modifiers include:
- headache
- dizziness
- nausea and vomiting
- myalgia.
Number 1 for children
Mast cell stabilizers are often used for children and patients with exercise-induced asthma.
Warning!
Adverse reactions to mast cell stabilizers
Inhaled mast cell stabilizers may cause these adverse reactions:
- pharyngeal and tracheal irritation
- cough
- wheezing
- bronchospasm
- headache.
Drug interactions
Interactions are uncommon when using inhaled forms.
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