Proton pump inhibitor use and risk of adverse cardiovascular events in aspirin treated patients with first time myocardial infarction: nationwide propensity score matched study
British Medical Journal, 05/26/2011 Clinical Article
Charlot M et al. – In aspirin treated patients with first time myocardial infarction, treatment with proton pump inhibitors was associated with an increased risk of adverse cardiovascular events.
Methods
Methods
- Retrospective nationwide propensity score matched study based on administrative data.
- All aspirin treated patients surviving 30 days after a first myocardial infarction from 1997 to 2006, with follow–up for one year.
- Patients treated with clopidogrel were excluded.
- The risk of the combined end point of cardiovascular death, myocardial infarction, or stroke associated with use of proton pump inhibitors was analysed using Kaplan–Meier analysis, Cox proportional hazard models, and propensity score matched Cox proportional hazard models.
- 3366 of 19 925 (16.9%) aspirin treated patients experienced recurrent myocardial infarction, stroke, or cardiovascular death.
- The hazard ratio for the combined end point in patients receiving proton pump inhibitors based on the time dependent Cox proportional hazard model was 1.46 (1.33 to 1.61; P<0.001) and for the propensity score matched model based on 8318 patients it was 1.61 (1.45 to 1.79; P<0.001).
- A sensitivity analysis showed no increase in risk related to use of H2 receptor blockers (1.04, 0.79 to 1.38; P=0.78).
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