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Home » , , » Adrenaline intravenous infusion calculations
Adrenaline intravenous infusion calculations
Thursday, September 29, 2011 Posted by Piscean


Adrenaline intravenous infusion calculations

Use adrenaline 0.1% or 1:1000 solution which is 1 mg/mL [NB1] [NB2] [NB3].
Adults:
The standard infusion rate for adults ranges from 1 to 20 micrograms/minute (60 to 1200 micrograms/hour). For more detail on requirements in anaphylaxis, see Table 14.15.
Infusion rates should be initiated at the lower end of the above ranges but can be titrated up approximately every 3 minutes to achieve the desired effects on blood pressure and heart rate.
For 50 mL bag or syringe driver, use:
3 mg/50 mL, which gives an infusion concentration of 60 micrograms/mL.
Therefore run infusion at 1 to 20 mL/hour to deliver 1 to 20 micrograms/minute.
For 100 mL bag, use:
6 mg/100 mL, which gives an infusion concentration of 60 micrograms/mL.
Therefore run infusion at 1 to 20 mL/hour to deliver 1 to 20 micrograms/minute.
For 1000 mL bag, use:
6 mg/1000 mL, which gives an infusion concentration of 6 micrograms/mL.
Therefore run infusion at 10 to 200 mL per hour to deliver 1 to 20 micrograms/minute.
Children:
For child 30 kg or less, use:
0.3 mg/kg in 50 mL so that 1 mL/hour gives 0.1 micrograms/kg/minute.
For child more than 30 kg, use:
0.15 mg/kg in 50 mL so that 1 mL/hour gives 0.05 micrograms/kg/minute.

NB1: Adrenaline is compatible with most standard infusion solutions. In most hospital emergency departments, glucose 5% is used to maintain consistency with use in the intensive care setting, but sodium chloride 0.9% is preferred in management of anaphylaxis.
NB2: Adrenaline dose terminology
Percent
Ratio
Concentration
0.01%
1 in 10 000
1 mg in 10 mL
0.1%
1 in 1000
1 mg/mL (most commonly available)
1%
1 in 100
10 mg/mL
NB3: Noradrenaline is available as a 1:1000 solution, and the same calculations apply to its preparation and use.

Piscean

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