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Sodium
Monday, September 19, 2011 Posted by Piscean


Sodium
Sodium is the major cation in ECF. Sodium performs many functions:
  • It maintains the osmotic pressure and concentration of ECF, acid-base balance, and water balance.
  • It contributes to nerve conduction and neuromuscular function.
  • It plays a role in glandular secretion.
Don’t sweat it
Sodium replacement is necessary in conditions that rapidly deplete sodium, such as anorexia, excessive loss of GI fluids, and excessive perspiration. Diuretics and tap water enemas can also deplete sodium, particularly when fluids are replaced by plain water.
The salt flats
Sodium also can be lost in trauma or wound drainage, adrenal gland insufficiency, cirrhosis of the liver with ascites, syndrome of inappropriate antidiuretic hormone, and prolonged I.V. infusion of dextrose in water without other solutes.
image
Calling all chlorides
Sodium is typically replaced in the form of sodium chloride.
Pharmacokinetics
Oral and parenteral sodium chloride are quickly absorbed and distributed widely throughout the body.
Metabolism and excretion
Sodium chloride isn’t significantly metabolized. It’s eliminated primarily in urine but also in sweat, tears, and saliva.
Pharmacodynamics
Sodium chloride solution replaces deficiencies of the sodium and chloride ions in the blood plasma.

Pharmacotherapeutics
Sodium chloride is used for water and electrolyte replacement in patients with hyponatremia from electrolyte loss or severe sodium chloride depletion.
A welcome infusion
Severe symptomatic sodium deficiency may be treated by I.V. infusion of a solution containing sodium chloride.
Drug interactions
No significant drug interactions have been reported with sodium chloride. (See Adverse reactions to sodium.)

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