Clicking moves left

Enhanced Elimination in Toxicology

Enhanced Elimination in Toxicology Extracorporeal eliminationExtracorpore [...]

Decontamination in Toxicology

Decontamination in ToxicologyorHow to Decontamination in ToxicologySingle-dose [...]

Resuscitation in Toxicology

Resuscitation in ToxicologySupportive careInitial resuscitation should be based [...]

Key investigations of Toxicology

Key investigations of Toxicology In this topic: Electrocardiography Drug conce [...]

Arterial blood gases in Toxicology

Arterial blood gases in Toxicology Arterial blood gases are an important in [...]

Clicking moves right
M O V I E
TRAVELING
Pharmacology of Disopyramide
31 Mar 2012 0 comments

Pharmacology of Disopyramide Indication For the treatment of documented ventricular arrhythmias, such as [...]

Pharmacology of Ranolazine
31 Mar 2012 0 comments

Pharmacology of Ranolazine Indication For the treatment of chronic angina. It should be used in combinati [...]

Pharmacology of Milrinone
31 Mar 2012 0 comments

Pharmacology of Milrinone Indication Indicated for the treatment of congestive heart failure. Pharma [...]

Pharmacology of Midodrine
31 Mar 2012 0 comments

Pharmacology of Midodrine   Indication For the treatment of symptomatic orthostatic hypotension [...]

Pharmacology of Dofetilide
31 Mar 2012 0 comments

Pharmacology of Dofetilide  Indication For the maintenance of normal sinus rhythm (delay in time to [...]

GALLERY
Classification of Anxiety Disorders
10 Mar 2012 0 comments

Anxiety disorders may be classified asgeneralized anxiety disorder, panic disorder, obsessive-compu [...]

Post-Traumatic Stress Disorder
10 Mar 2012 0 comments

Post-Traumatic Stress DisorderPost-traumatic stress disorder develops following a traumatic event that elicit [...]

Social Anxiety Disorder
10 Mar 2012 0 comments

Social Anxiety DisorderSocial anxiety disorder, formerly known as social phobia, is characterized by an inten [...]

TOP LINE
Classification of Anxiety Disorders
10 Mar 2012 0 comments

Anxiety disorders may be classified asgeneralized anxiety disorder, panic disorder, obsessive-compulsive disorder, social anxiety disorder, post-traumatic stress disorder. Click to view each type....

Post-Traumatic Stress Disorder
Social Anxiety Disorder
Obsessive-Compulsive Disorder
Panic Disorder
Generalized Anxiety Disorder
REVIEW
Hormonal contraceptives
25 Apr 2011 0 comments

Hormonal contraceptivesHormonal contraceptives inhibit ovulation. Contraceptives typically contain a combination of hormones. Fo...

Erectile dysfunction therapy drugs

Erectile dysfunction therapy drugsErectile dysfunction therapy drugs treat penile erectile dysfunction that results from a lack ...

Urinary tract antispasmodics

Urinary tract antispasmodicsUrinary tract antispasmodics help decrease urinary tract muscle spasms. They include darifenacin, fl...

ANALYSIS
Pharmacology of Disopyramide
31 Mar 2012 0 comments

Pharmacology of Disopyramide Indication For the treatment of documented ventricular arrhythmias, such as sustained ventricul...

Pharmacology of Ranolazine

Pharmacology of Ranolazine Indication For the treatment of chronic angina. It should be used in combination with amlodipine, ...

Pharmacology of Milrinone

Pharmacology of Milrinone Indication Indicated for the treatment of congestive heart failure. Pharmacodynamics Milri...

HIGHLIGHT
[ more from label ]
Classification of Anxiety Disorders
Post-Traumatic Stress Disorder
Social Anxiety Disorder
Obsessive-Compulsive Disorder
Latest News Updates
PERFORMANCE
Pharmacology of Disopyramide
31 Mar 2012 0 comments

Pharmacology of Disopyramide Indication For the treatment of documented ventricular arrhythmias, such as ...

Pharmacology of Ranolazine
Pharmacology of Milrinone
FEATURE
Classification of Anxiety Disorders
10 Mar 2012 0 comments

Anxiety disorders may be classified asgeneralized anxiety disorder, panic disorder, obsessive-compu...

Post-Traumatic Stress Disorder
Social Anxiety Disorder
Home » , , » Specific toxicology treatments and antidotes: activated charcoal
Specific toxicology treatments and antidotes: activated charcoal
Friday, September 9, 2011 Posted by Piscean


Specific toxicology treatments and antidotes: activated charcoal
Activated charcoal is manufactured by superheating distilled wood pulp, which creates a substance with a very large surface area that reversibly adsorbs many ingested toxins. It reduces the systemic absorption of drugs and poisons by binding the substance in the gastrointestinal tract and increasing clearance of some drugs/toxins by interruption of enterohepatic circulation or gastrointestinal dialysis, ie the drawing of already absorbed drugs/toxins back into the gastrointestinal tract down a concentration gradient, allowing subsequent excretion.

The effectiveness of charcoal in adsorbing a drug or toxin is dependent on:
  • the drug/toxin's binding to charcoal
  • the normal absorption properties of the drug/toxin
  • any drug effect on gastrointestinal activity (eg ileus).
The effectiveness of charcoal in clearing a drug appears to depend on the normal clearance of the drug and enterohepatic recirculation of the drug.
Activated charcoal is generally administered in a sucrose-containing oral liquid. Formulation with the cathartic, sorbitol, provides no advantage. Tablets and capsules of activated charcoal are ineffective in acute poisonings.
Activated charcoal is unlikely to be effective for alcohols (including ethanol, ethylene glycol and methanol), strong acids and alkalis (corrosives) or metals (including gold, lithium, iron and potassium).
Activated charcoal should not be used where it is unlikely to provide measurable clinical benefit and/or where it is expected that good supportive care and antidote therapy alone would deliver a good outcome.
Activated charcoal can be taken orally by conscious and cooperative patients. Mixing it with ice-cream or other such food can improve palatability in children. It can be administered via an orogastric or nasogastric tube to conscious patients unable to take the dose orally, or to unconscious patients who have a protected airway.
Multiple-dose activated charcoal has been shown to increase clearance of some drugs. This effect is probably due to an extension of the effect of single-dose activated charcoal by extending the period charcoal is present in the gastrointestinal tract. This technique may have a role in severe overdoses of carbamazepine, phenobarbitone, dapsone, quinine and theophylline. Prior to each dose of activated charcoal the presence of bowel sounds must be confirmed.

Piscean

Thanks for your visit..!

0 comments for "Specific toxicology treatments and antidotes: activated charcoal"

   

Leave a reply

    March - 2025
    SMTWTFS
          1
    2345678
    9101112131415
    16171819202122
    23242526272829
    3031