Specific toxicology treatments and antidotes: dicobalt edetate
| Specific toxicology treatments and antidotes: dicobalt edetate |
Dicobalt edetate is an antidote for symptomatic cyanide poisoning. The cobalt binds to cyanide to form a stable complex that is significantly less toxic than free cyanide. These complexes are excreted in the urine. Dicobalt edetate is capable of crossing the blood-brain barrier. It is administered by intravenous bolus injection.
Adverse effects may be life-threatening and include seizures, extensive facial and laryngeal oedema, chest pain, cardiac dysrhythmias, dyspnoea, profound hypotension, vomiting and urticaria. These reactions may be more common when dicobalt edetate is given to a patient who does not actually have cyanide poisoning. Therefore, this drug should only be administered in severe cases where cyanide poisoning is highly likely.
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