Pharmacology Notes: Approximate equianalgesic doses of various opioids (Table 1.4) [NB1]

Home » Analgesics, Therapeutic Guidelines, Therapeutics » Approximate equianalgesic doses of various opioids (Table 1.4) [NB1]

Approximate equianalgesic doses of various opioids (Table 1.4) [NB1]

Monday, October 31, 2011 Posted by Piscean

Approximate equianalgesic doses of various opioids (Table 1.4) [NB1]

Opioid	Oral	Parenteral
morphine	30 mg	10 mg IM/IV/SC [NB2]
codeine oral	180 to 240 mg	–
fentanyl [NB3]	–	100 micrograms IV/IM/SC/epidural
hydromorphone	6 to 7.5 mg	1.5 to 2 mg IM/SC
methadone	[NB4]	[NB4]
oxycodone	15 mg	10 mg IV/SC
pethidine	–	75 to 100 mg IM/SC
tramadol [NB5]	100 to 150 mg	100 mg IM/IV
NB1: These are average equivalent doses because of pharmacokinetic variation between individuals. When changing from one opioid to another, commence with one-third to one-half of the calculated equianalgesic dose and then titrate to response. NB2: See Table 1.6 for other routes of morphine administration. NB3: For conversion of morphine to transdermal fentanyl patches, see fentanyl product information. NB4: Care needs to be taken with methadone to avoid toxicity because the time to reach steady-state concentrations following a change in dosage may be up to 12 days. Dose conversion ratios from other opioids are not static, but are a function of previous opioid exposure, and are highly variable . Consultation with a pain clinic or a palliative care service is advised. NB5: Tramadol may not be suitable for patients with moderate to severe pain.

Piscean

Thanks for your visit..!

Pharmacology Notes