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Home » , , , » Approximate relative potency and half-lives of oral corticosteroids (Table 5.34)
Approximate relative potency and half-lives of oral corticosteroids (Table 5.34)
Wednesday, November 2, 2011 Posted by Piscean



Approximate relative potency and half-lives of oral corticosteroids (Table 5.34)
Corticosteroid
Relative glucocorticoid potency
Equivalent dose for glucocorticoid effect
Plasma half-life
Estimated biological half-life
hydrocortisone
1
20 mg
90 minutes
8 to 12 hours

cortisone acetate
0.8
25 mg
30 minutes
8 to 12 hours

dexamethasone
25
750 micrograms
200 minutes
36 to 54 hours

fludrocortisone
10
2 mg [NB1]
[NB3]
18 to 36 hours

prednisone
3.5
5 mg
60 minutes [NB2]
18 to 36 hours
prednisolone
4
5 mg
200 minutes
18 to 36 hours
methylprednisolone
5
4 mg
180 minutes
12 to 36 hours

NB1: see chapter 14, 'Adrenal cortex', in Williams RH, Larsen PR, Kronenberg HM, Melmed S, Polonsky KS, Wilson JD, Foster DW, eds. Williams Textbook of Endocrinology. 10th ed. W B Saunders; 2002.
NB2: preconversion half-life to prednisolone
NB3: consistent information not available

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