Distribution
The systemic circulation distributes drugs to various body tissues or target sites. Drugs interact with specific receptors (see Fig.) during distribution. Some drugs travel by binding to protein (albumin) in the blood. Drugs bound to protein are pharmacologically inactive. Only when the protein molecules release the drug can the drug diffuse into the tissues, interact with receptors, and produce a therapeutic effect.
As the drug circulates in the blood, a certain blood level must be maintained for the drugs to be effective. When the blood level decreases below the therapeutic level, the drug will not produce the desired effect. Should the blood level increase significantly over the therapeutic level, toxic symptoms develop. Specific therapeutic blood levels are discussed in the subsequent chapters when applicable.
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| Drug-receptor interactions |
As the drug circulates in the blood, a certain blood level must be maintained for the drugs to be effective. When the blood level decreases below the therapeutic level, the drug will not produce the desired effect. Should the blood level increase significantly over the therapeutic level, toxic symptoms develop. Specific therapeutic blood levels are discussed in the subsequent chapters when applicable.
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