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Major drugs uses, Action and Adrs
Thursday, July 21, 2011 Posted by Piscean

Major drugs uses, Action and Adrs

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OPHTHALMIC DRUGS


Drug Action Treatment uses Adverse reactions
Antiallergic agents


Azelastine
  • Decrease irritation
  • To treat allergic conjunctivitis
  • Tearing
Cromolyn
  • To treat seasonal conjunctivitis

Emedastine
  • To treat keratitis

Ketotifen


Lodoxamide


Olopatadine


Anesthetics


Proparacaine
  • Prevent the initiation and transmission of nerve impulses
  • To anesthetize the cornea, allowing application of instruments for measuring intraocular pressure (I0P) or removing foreign bodies
  • Corneal inflammation
Tetracaine

  • Corneal opacities



  • Delayed corneal healing



  • Eye pain and redness


  • To prepare for suture removal, conjunctival or corneal scraping, and tear duct manipulation
  • Loss of visual acuity



  • Scarring
Anti-infectives


Ciprofloxacin
  • Kill bacteria or inhibit growth of bacteria or viruses
  • To treat corneal ulcers or conjunctivitis caused by bacteria, fungus, or virus (each drug is specific to particular organisms)
  • Secondary eye infections (with prolonged use)
Erythromycin


Gentamicin

  • Severe hypersensitivity reactions
Levofloxacin


Natamycin


Norfloxacin


Ofloxacin


Sulfacetamide


Sulfisoxazole


Tobramycin


Trifluridine


Anti-inflammatories


Steroidalanti-anti-inflammatories
  • Decrease leukocyte infilinfiltration at inflammation sites, causing reduced oozing of fluids and reduced edema, redness, and scarring
  • To treat inflammatory disorders and hypersensitivity-related conditions of the cornea, iris, conjunctiva, sclera, and anterior uvea
  • Corneal ulcĂ©ration



  • Delayed corneal healing
Dexamethasone

  • Increased susceptibility to viral or fungal corneal infection
Fluorometholone


Loteprednol


Prednisolone


Rimexolone


Nonsteroidal anti-inflammatories
  • Decrease inflammation and itching
  • To inhibit pupil constriction during surgery (flurbiprofen and suprofen)
  • Tearing, discomfort
Diclofenac
  • To reduce itching due to seasonal allergies (ketorolac)

Flurbiprofen


Ketorolac
  • To treat inflammation after surgery

Suprofen


Lubricants


Methylcellulose
  • Act as artificial tears
  • To protect cornea during diagnostic procedures
  • None
Polyvinyl alcohol
  • Moisten cornea




  • To moisten contact lenses

Miotics


Carbachol
  • Stimulate and contract the sphincter muscle of the iris, constricting the pupil
  • To treat open-angle glaucoma, acute and chronic angle-closure glaucoma, and certain cases of secondary glaucoma resulting from increased IOP
  • Blurred vision
Pilocarpine
  • Improve aqueous outflow

  • Bronchospasm



  • Cataractformation



  • Eye pain



  • Photosensitivity



  • Reversible iris cysts
Mydriatics


Dipivefrin
  • Acton the iris to dilate the pupil
  • To dilate the pupils for intraocular examinations
  • Blurred vision
Epinephrine

  • Confusion
Hydroxyamphetamine
  • Lower I0P
  • To lower I0P in patients with glaucoma
  • Dry skin
Phenylephrine


  • Flushing



  • Impaired ability to coordinate movement



  • Irritation



  • Rapid heart rate



  • Transient burning sensations
Mydriatics and cycloplegics


Atropine sulfate
  • Act on the ciliary body of the eye to paralyze the fine-focusing muscles (thereby preventing accommodation for near vision)
  • To perform refractive eye examinations in children before and after ophthalmic surgery
  • Same as for mydriatics
Cyclopentolate hydrochloride


Homatropine hydrobromide
  • To treat conditions involving the iris

Tropicamide


Other drugs to lower IOP


Adrenergic blockers (topical)
  • May reduce aqueous humor formation and slightly increase aqueous humor outflow
  • To prevent and control elevated IOP, chronic open-angle glaucoma, and secondary glaucoma
  • Bronchospasm



  • Fatigue
Apraclonidine

  • Headaches
Betaxolol outflow
Slow heart rate
Brimonidine


Carteolol


Levobunolol


Metipranolol


Timolol maleate


Carbonic anhydrase inhibitors
  • Inhibit action of carbonic anhydrase, thus decreasing aqueous humor production
  • To treat chronic open angle glaucoma, acute angle-closure episodes, and secondary glaucoma
  • Hemolytic or aplastic anemia



Hypokalemia
Acetazolamide

Leukopenia
Brinzolamide

Nausea and vomiting
Dorzolamide


Osmotic agents Glycerin
  • Reduce volume of vitreous humor
To prepare for intraocular surgery «Hypokalemia


To treat acute glaucoma «Diuresis
Isosorbide Decrease IOP

Mannitol


Prostaglandin analogues
  • Decrease IOP
To treat glaucoma «Irritation



Tearing
Bimatoprost


Latanoprost


Travoprost


Unoprostone


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OTIC DRUGS


Drug Action Treatment uses Adverse reactions
Anesthetics (local)


Benzocaine
  • Temporarily interrupt the conduction of nerve im-pulses
  • To temporarily relieve ear pain
  • Ear irritation or itching
  • Edema
  • Hives
  • Masking of the symptoms of a fulminating middle ear infection
Anti-infectives


Acetic acid
  • Kill bacteria or inhibit bacterial growth
  • Inhibit fungal growth (acetic acid and boric acid)
  • To treat otitis externa
  • To treat otitis media (colistin and polymyxin B sulfate)
  • Burning
  • Dermatitis
  • Ear itching
  • Hives
Boric acid


Chloramphenicol


Colistin sulfate


Neomycin sulfate


Polymyxin B sulfate


Anti-inflammatories
Hydrocortisone
  • Inhibit edema, capillary dilation, fibrin deposition, and phagocyte and leuko-cyte migration
  • Reduce capillary and fi-broblast proliferation, col-lagen deposition, and scar formation
  • To treat inflammatory conditions of the external ear canal
  • Masking or exacerbation of underlying otic infection
  • Transient local stinging or burning sensations
Dexamethasone-sodium phosphate


Cerumenolytics


Carbamide peroxide Triethanolamine polypeptide
  • Reduce hardened ceru-men by emulsifying and mechanically loosening it
  • To loosen and remove cerumen from the ear canal
  • Mild, localized redness and itching

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DERMATOLOGIC DRUGS


Drug Action Treatment uses Adverse reactions
Anti-infectives


Antibacterials
Azelaic acid
Bacitracin
Clindamycin
Erythromycin
Gentamicin
Mafenide
Metronidazole
Mupirocin
Neomycin
Silver sulfadiazine
Sulfacetamide sodium
Tetracycline
  • Kill or inhibit the growth of bacteria
  • To treat infections caused by bacteria (each drug is specific to particular organisms; combination products may also be used)
  • Contact dermatitis
  • Rash
  • Skin burning, itching, and red-ness
  • Skin dryness
  • Stinging
Antifungals
Amphotericin B
Butenafine
Ciclopirox
Clotrimazole
Econazole
Ketoconazole
Miconazole
Naftifine
Nystatin
Oxiconazole
Sulconazole
Terbinafine
  • Kill or inhibit the growth of fungiof bacteria
  • To treat infections caused by fungi (each drug is specific to particular or-ganisms)
  • Same as for antibacterials
Antivirals
Acyclovir
Penciclovir
  • Inhibit the growth of herpes virus
  • To treat herpes genitalis or herpes labialis
  • Same as for antibacterials
Anti-inflammatories Alclometasone
Betamethasone dipropionate
Clobetasol
Clocortolone
Desonide
Desoximetasone
Dexamethasone
Diflorasone diacetate
Fluocinolone
Fluocinonide
Flurandrenolide
Fluticasone
Halcinonide
Halobetasol
Hydrocortisone
Mometasone
Triamcinolone acetonide
  • Suppress inflammation by binding to intracellular corticosteroid receptors, initiating a cascade of anti-inflammatory mediators
  • Cause vasoconstriction in inflamed tissue and pre-vent macrophages and leukocytes from moving into the area
  • To relieve inflammation and itching in topical steroid-responsive disorders, such as eczema, psoriasis, angioedema, contact dermatitis, sebor-rheic dermatitis, atopic dermatitis, and hives
Hair growth stimulants


Minoxidil
  • Stimulate hair growth by causing vasodilation, which increases blood flow to the skin (exact mecha-nism of action is unknown)
  • To treat male and female pattern baldness
  • Fluid retention
  • Rapid heart rate
  • Weight gain
Topical antiacne drugs


Keratolytics
Acitretin
Adapalene
Isotretinoin
Tazarotene
Tretinoin
Counterirritants
Benzoyl peroxide
  • Produce antibacterial effects
  • Reduce inflammation
  • Produce antibacterial effects
  • Reduce inflammation
  • To treat mild acne, oily skin, and acne vulgaris (oral antibiotic therapy used as needed for deep acne)
  • To treat mild acne, oily skin, and acne vulgaris (oral antibiotic therapy used as needed for deep acne)
  • Burning
  • Hives
  • Rash
  • Scaling, blistering, and peeling
  • Skin dryness
  • Skin irritation
  • Superinfection (with prolonged use)
    • Same as for keratolytics
Antimicrobials
Clindamycin
Doxycycline
Erythromycin
Minocycline
Tetracycline
  • Produce antibacterial effects
  • Reduce inflammation
  • To treat mild acne, oily skin, and acne vulgaris (oral antibiotic therapy used as needed for deep acne)
  • Same as for keratolytics
  • Hypersensitivity reactions (oral)
  • Candidal vaginitis (oral)
  • Gram-negative pustular folliculitis (oral)
Scabicides and pediculicides


Gamma benzene
hexachloride
Lindane
Malathion
Permethrin
  • Act on parasite nerve cell membranes to disrupt the sodium channel current, causing paralysis (some are also ovicidal)
  • To treat scabies and lice
  • Contact dermatitis
  • Hypersensitivity reactions
  • Respiratory allergy symptoms

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