The distribution and metabolism of carboplatin aren’t defined clearly. After I.V. administration, carboplatin is eliminated primarily by the kidneys. The elimination of carboplatin is biphasic. It has an initial half-life of 1 to 2 hours and a terminal half-life of 2½ to 6 hours. In patients with decreased renal function, the terminal half-life of carboplatin may last from 30 to 300 hours.Oxaliplatin is 70% to 90% bound to plasma proteins, and the protein-binding increases over time. It’s widely distributed into most body tissues and is eliminated in phases.

When administered intrapleurally (into the pleural space around the lung) or intraperitoneally (into the peritoneum), cisplatin may exhibit significant systemic absorption. Highly protein bound, cisplatin reaches high concentrations in the kidneys, liver, intestines, and testes but has poor central nervous system (CNS) penetration. The drug undergoes some liver metabolism, followed by excretion through the kidney.

 

Platinum is detectable in tissue for at least 4 months after administration.