Antiviral drugs: adefovir
Antiviral drugs: adefovir |
Adefovir is a nucleotide analogue of adenosine with activity against the hepatitis B virus. It is taken orally as a prodrug (adefovir dipivoxil) and is active against wild type hepatitis B virus and lamivudine-resistant variants.
The most common adverse effect of adefovir is gastric intolerance. It can also cause renal impairment.
Adefovir is eliminated predominantly by renal excretion with a half-life of about 8 hours in patients with normal kidney function. Reduced dosage frequency is required in renal impairment.
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