Pharmacology Notes

Lamivudine is a nucleoside reverse transcriptase inhibitor developed for treating human immunodeficiency virus infection . It is also used in the treatment of chronic hepatitis B in those with evidence of hepatitis B virus replication. It is given orally and adverse effects are uncommon. When used as monotherapy for hepatitis B, the major limitation of lamivudine is the development of viral resistance (69% after 4 years).